John Barrymore

Dr. Henry Jekyll / Mr. Edward Hyde

Brandon Hurst

Sir George Carewe

Martha Mansfield

Millicent Carewe

Nita Naldi

Miss Gina

Louis Wolheim

Music Hall Proprietor

Ferdinand Gottschalk

Old Man at Table in Music Hall (uncredited)

Julia Hurley

Hyde's Landlady with Lamp (uncredited)

May Robson

Prostitute at Clinic (uncredited)

Edgard Varèse

Policeman (uncredited)